34 volunteers chose to get covid. Here’s what scientists learned | The Business Standard
Skip to main content
  • Latest
  • Economy
    • Banking
    • Stocks
    • Industry
    • Analysis
    • Bazaar
    • RMG
    • Corporates
    • Aviation
  • Videos
    • TBS Today
    • TBS Stories
    • TBS World
    • News of the day
    • TBS Programs
    • Podcast
    • Editor's Pick
  • World+Biz
  • Features
    • Panorama
    • The Big Picture
    • Pursuit
    • Habitat
    • Thoughts
    • Splash
    • Mode
    • Tech
    • Explorer
    • Brands
    • In Focus
    • Book Review
    • Earth
    • Food
    • Luxury
    • Wheels
  • More
    • Sports
    • TBS Graduates
    • Bangladesh
    • Supplement
    • Infograph
    • Archive
    • Gallery
    • Long Read
    • Interviews
    • Offbeat
    • Magazine
    • Climate Change
    • Health
    • Cartoons
  • বাংলা
The Business Standard

Wednesday
June 11, 2025

Sign In
Subscribe
  • Latest
  • Economy
    • Banking
    • Stocks
    • Industry
    • Analysis
    • Bazaar
    • RMG
    • Corporates
    • Aviation
  • Videos
    • TBS Today
    • TBS Stories
    • TBS World
    • News of the day
    • TBS Programs
    • Podcast
    • Editor's Pick
  • World+Biz
  • Features
    • Panorama
    • The Big Picture
    • Pursuit
    • Habitat
    • Thoughts
    • Splash
    • Mode
    • Tech
    • Explorer
    • Brands
    • In Focus
    • Book Review
    • Earth
    • Food
    • Luxury
    • Wheels
  • More
    • Sports
    • TBS Graduates
    • Bangladesh
    • Supplement
    • Infograph
    • Archive
    • Gallery
    • Long Read
    • Interviews
    • Offbeat
    • Magazine
    • Climate Change
    • Health
    • Cartoons
  • বাংলা
WEDNESDAY, JUNE 11, 2025
34 volunteers chose to get covid. Here’s what scientists learned

Panorama

Faye Flam
08 May, 2022, 10:25 am
Last modified: 08 May, 2022, 04:13 pm

Related News

  • Aid funding disrupts child vaccinations almost as much as pandemic: UN
  • Trump's White House launches COVID website that criticizes WHO, Fauci and Biden
  • Chinese researchers find bat virus enters human cells via same pathway as Covid
  • Forgotten but not gone: Covid keeps killing, five years on
  • Yes, everyone really is sick a lot more often after covid

34 volunteers chose to get covid. Here’s what scientists learned

Faye Flam
08 May, 2022, 10:25 am
Last modified: 08 May, 2022, 04:13 pm
34 volunteers chose to get covid. Here’s what scientists learned

Jacob Hopkins, 24, tried hard not to get Covid-19 in the months leading up to March 2021, when, if he succeeded, he could be part of a unique experiment in which he was deliberately infected with the virus. Almost a year earlier, he had put his name on a list of volunteers. Months went by until, on 23 December, he finally heard back from someone associated with the experiment.  He ended up being the very first volunteer given the infection — patient 1.
As he described it to me, he took a cab to a hospital in London, wearing a mask so he would be sure not to catch Covid at the last minute. He arrived on a Friday, went through a battery of tests over two days, and on Monday, five health-care workers came in wearing full PPE, "like something out of the movie 'Contagion,'" pulling in a tank of solution containing SARS-CoV-2.

They had him lie at the edge of the bed with his head back and squirted the infectious solution up his nose. He was one of 34 volunteers.

This kind of experiment is called a "challenge" trial. Thanks to Hopkins and the other volunteers, researchers learned some fascinating details about viral loads, symptoms and incubation times. A paper on the findings was published in Nature on March 31 of this year.

The Business Standard Google News Keep updated, follow The Business Standard's Google news channel

I'd written about challenge trials in May 2020, and was so compelled by the idea that I put my name on a list of volunteers that scientists could call on if they organized such a trial. I thought I was a good candidate because I had no conditions that would make me unusually vulnerable to Covid-19. Because of the nature of my work, I could call on the world's top experts to advise me about safety and scientific value of any trial I might enter.

At the time, nobody knew how long it would take to get vaccines tested and approved. Challenge trials have been used to study malaria and influenza and looked like a possible shortcut to speed up arrival of a Covid-19 vaccine. For me, the experience would have led to a series of great stories. Journalists do far more dangerous things for work.

But events took a surprising turn. Standard vaccine trials progressed with record speed and the first vaccine candidates looked impressively effective. By the end of 2020, vaccines were already being offered to health-care workers in some places. I'd assumed any challenge trials would have been called off.

But the challenge trial Hopkins took part in did go forward. "We started with the lowest dose we can reliably produce," said Christopher Chiu, a researcher at Imperial College London, who headed the experiment. If nobody got infected they'd step up the dose, slightly, he said, but on the first try, they got slightly past 50% — infecting 18 of 34 volunteers.

Chiu said they are only beginning to learn from the data they've accumulated. Two of the 18 infected had no symptoms at all, and the rest had mild or moderate symptoms — mostly sore throats and runny noses.

One of the first big surprises was how short the incubation period was, Chiu told me. It was only two days before the volunteers who got infected tested positive on PCR tests and not much longer to register a positive on rapid tests. Those who got symptoms noticed them between two and four days after exposure.

Another surprise was that the amount of virus people produced didn't reflect the severity of their symptoms — those who produced a lot of virus sometimes had very mild or no symptoms and those who felt sicker sometimes produced less.

Since the date of exposure was known, the data were also useful for examining testing efficacy. While rapid tests didn't always pick up the infection as early as the more sensitive PCR test, Chiu said it appeared to pick up most infections around the time that would likely coincide with peak transmissibility.

Chiu said everyone recovered quickly from all the symptoms except for changes in taste and smell. Those lasted for around six months in five of the volunteers, and one was still reporting a diminished sense of smell nine months after exposure.

Since this experiment took place, there's been big increase in the awareness of the risk of lingering or even permanent symptoms, and several studies have hinted at the possibility of long-term changes in the heart and brain, though scientists are still trying to figure out if the subtle changes have real health significance.

Hopkins, who works for the charity group Citizens' Advice, said he was well aware of the risk of long Covid, but thinks it was outweighed by the benefit of being part of the fight against the pandemic. He feels that the researchers fully informed him of the risks of infection and what would be involved in the experiment. He told me he is a risk-taker by nature, and recently went skydiving in Dubai. "I love adrenaline," he said. And he's deeply interested in medical research and has donated stem cells to people with blood cancers.

The course of his illness was brief. He was infected on a Monday, tested positive on Wednesday and started feeling chills on Thursday. He said he had flulike symptoms that were "pretty rough" but lasted only two days. Then, a few days after feeling better, while still in isolation and undergoing tests, he failed a smell test. Odors on the test that had been strong before his infection smelled like absolutely nothing. Then a few days later, his sense of smell returned.

Challenge trials give scientists a uniquely controlled data set, helping them gauge things like incubation time, accuracy of tests and long-term consequences of infection. They may reveal something about why some people get sick and others don't. It's the kind of controlled, experimental data that's been so badly lacking in a pandemic that's been ruled by educated guesses announced with inappropriate certainty.

The situation has changed a lot since this experiment was done. We're contending with descendants of Omicron — BA.2, BA.2.121, BA.4 and BA.5, and almost everyone in the U.K. and the U.S. has some degree of immunity to some version of the virus. But the challenge trial data could nevertheless be extremely useful right now. Those data suggest that people who test positive may remain infectious far longer than the five days they're supposed to quarantine. And for those potentially exposed, the data could be turned into better information on when to use home or PCR tests, and how much people can rely on the results. The challenge trial results also open up new scientific questions, including why some people resist getting infected at all — even when the virus is sprayed directly up their noses.


Faye Flam is a Bloomberg Opinion columnist and host of the podcast "Follow the Science."
 

Disclaimer: This article first appeared on Bloomberg, and is published by special syndication arrangement.
 

Coronavirus chronicle / Features / Top News

Covid -19 / Coronavirus

Comments

While most comments will be posted if they are on-topic and not abusive, moderation decisions are subjective. Published comments are readers’ own views and The Business Standard does not endorse any of the readers’ comments.

Top Stories

  • Maintaining a cordial relationship between patients and doctors at this tense time of an ongoing pandemic is more important than ever before. Photo: Mumit M
    Covid-19 testing to resume at hospitals amid rising infections
  • Members of law enforcement work to clear the area, as protests against federal immigration sweeps continue, in downtown Los Angeles, California, US June 10, 2025. Photo: REUTERS
    US cities brace for more protests as parts of Los Angeles placed under curfew
  • Chief Adviser Professor Dr Muhammad Yunus (L) and British Prime Minister Sir Keir Starmer (R). Photo: BSS
    UK PM visiting Canada, will meet CA if schedule matches: CA press secy

MOST VIEWED

  • Illustration: Duniya Jahan/ TBS
    Forget Katy Perry, here’s Bangladesh’s Ruthba Yasmin shooting for the moon
  • A file photo of Bangladesh Bank Governor Dr Ahsan H Mansur. Photo: Collected
    'I have no relation with this': Ahsan Mansur debunks Joy’s allegations over daughter’s Dubai flat
  • Faiz Ahmad Tayeb. Photo: BSS
    Import duty on raw materials for e-bikes, lithium batteries reduced from 80% to 1% in some cases: Faiz Taiyeb
  • Screengrab from video shows a group of local youths forcing tourists to leave a tourist spot in Utmachhra area of Sylhet's Companiganj on Sunday, 8 June 2025, citing allegations of obscene activities and environmental damage
    Locals declare tourist spot in Sylhet 'closed', force visitors to leave
  • Shakil Ahmed. Photo: Collected
    DU student allegedly hangs himself following threats over old derogatory comment about Prophet on Facebook
  • Photo shows the Land Cruiser Prado car belonging to former member of parliament (MP) Anwarul Azim Anar found in Kushtia. Photo: TBS
    Luxury car of ex-AL MP Anar, who was killed in Kolkata, found in Kushtia

Related News

  • Aid funding disrupts child vaccinations almost as much as pandemic: UN
  • Trump's White House launches COVID website that criticizes WHO, Fauci and Biden
  • Chinese researchers find bat virus enters human cells via same pathway as Covid
  • Forgotten but not gone: Covid keeps killing, five years on
  • Yes, everyone really is sick a lot more often after covid

Features

Illustration: Duniya Jahan/ TBS

Forget Katy Perry, here’s Bangladesh’s Ruthba Yasmin shooting for the moon

18h | Features
File photo of Eid holidaymakers returning to the capital from their country homes/Rajib Dhar

Dhaka: The city we never want to return to, but always do

2d | Features
Photo collage shows political posters in Bagerhat. Photos: Jannatul Naym Pieal

From Sheikh Dynasty to sibling rivalry: Bagerhat signals a turning tide in local politics

3d | Bangladesh
Illustration: TBS

Unbearable weight of the white coat: The mental health crisis in our medical colleges

6d | Panorama

More Videos from TBS

Curfew ordered in downtown Los Angeles after looting and vandalism

Curfew ordered in downtown Los Angeles after looting and vandalism

28m | TBS World
Israel kidnapped me in international waters: Greta Thunberg

Israel kidnapped me in international waters: Greta Thunberg

1h | TBS World
Is the chief adviser's meeting with the British Prime Minister uncertain?

Is the chief adviser's meeting with the British Prime Minister uncertain?

2h | TBS Stories
Aviation giants Airbus, Menzies seek long-time partnership with Bangladesh

Aviation giants Airbus, Menzies seek long-time partnership with Bangladesh

3h | TBS Stories
EMAIL US
contact@tbsnews.net
FOLLOW US
WHATSAPP
+880 1847416158
The Business Standard
  • About Us
  • Contact us
  • Sitemap
  • Advertisement
  • Privacy Policy
  • Comment Policy
Copyright © 2025
The Business Standard All rights reserved
Technical Partner: RSI Lab

Contact Us

The Business Standard

Main Office -4/A, Eskaton Garden, Dhaka- 1000

Phone: +8801847 416158 - 59

Send Opinion articles to - oped.tbs@gmail.com

For advertisement- sales@tbsnews.net