34 volunteers chose to get covid. Here’s what scientists learned | The Business Standard
Skip to main content
  • Latest
  • Economy
    • Banking
    • Stocks
    • Industry
    • Analysis
    • Bazaar
    • RMG
    • Corporates
    • Aviation
  • Videos
    • TBS Today
    • TBS Stories
    • TBS World
    • News of the day
    • TBS Programs
    • Podcast
    • Editor's Pick
  • World+Biz
  • Features
    • Panorama
    • The Big Picture
    • Pursuit
    • Habitat
    • Thoughts
    • Splash
    • Mode
    • Tech
    • Explorer
    • Brands
    • In Focus
    • Book Review
    • Earth
    • Food
    • Luxury
    • Wheels
  • More
    • Sports
    • TBS Graduates
    • Bangladesh
    • Supplement
    • Infograph
    • Archive
    • Gallery
    • Long Read
    • Interviews
    • Offbeat
    • Magazine
    • Climate Change
    • Health
    • Cartoons
  • বাংলা
The Business Standard

Thursday
June 12, 2025

Sign In
Subscribe
  • Latest
  • Economy
    • Banking
    • Stocks
    • Industry
    • Analysis
    • Bazaar
    • RMG
    • Corporates
    • Aviation
  • Videos
    • TBS Today
    • TBS Stories
    • TBS World
    • News of the day
    • TBS Programs
    • Podcast
    • Editor's Pick
  • World+Biz
  • Features
    • Panorama
    • The Big Picture
    • Pursuit
    • Habitat
    • Thoughts
    • Splash
    • Mode
    • Tech
    • Explorer
    • Brands
    • In Focus
    • Book Review
    • Earth
    • Food
    • Luxury
    • Wheels
  • More
    • Sports
    • TBS Graduates
    • Bangladesh
    • Supplement
    • Infograph
    • Archive
    • Gallery
    • Long Read
    • Interviews
    • Offbeat
    • Magazine
    • Climate Change
    • Health
    • Cartoons
  • বাংলা
THURSDAY, JUNE 12, 2025
34 volunteers chose to get covid. Here’s what scientists learned

Panorama

Faye Flam
08 May, 2022, 10:25 am
Last modified: 08 May, 2022, 04:13 pm

Related News

  • Covid hospitals in Chattogram face ICU, testing kit crisis amid rising infections
  • 10 more Covid-19 cases reported in country
  • DGHS issues 11-point directive to prevent spread of Covid-19 in Bangladesh
  • Tourist surge raises fresh Covid-19 concerns in Rangamati
  • Aid funding disrupts child vaccinations almost as much as pandemic: UN

34 volunteers chose to get covid. Here’s what scientists learned

Faye Flam
08 May, 2022, 10:25 am
Last modified: 08 May, 2022, 04:13 pm
34 volunteers chose to get covid. Here’s what scientists learned

Jacob Hopkins, 24, tried hard not to get Covid-19 in the months leading up to March 2021, when, if he succeeded, he could be part of a unique experiment in which he was deliberately infected with the virus. Almost a year earlier, he had put his name on a list of volunteers. Months went by until, on 23 December, he finally heard back from someone associated with the experiment.  He ended up being the very first volunteer given the infection — patient 1.
As he described it to me, he took a cab to a hospital in London, wearing a mask so he would be sure not to catch Covid at the last minute. He arrived on a Friday, went through a battery of tests over two days, and on Monday, five health-care workers came in wearing full PPE, "like something out of the movie 'Contagion,'" pulling in a tank of solution containing SARS-CoV-2.

They had him lie at the edge of the bed with his head back and squirted the infectious solution up his nose. He was one of 34 volunteers.

This kind of experiment is called a "challenge" trial. Thanks to Hopkins and the other volunteers, researchers learned some fascinating details about viral loads, symptoms and incubation times. A paper on the findings was published in Nature on March 31 of this year.

The Business Standard Google News Keep updated, follow The Business Standard's Google news channel

I'd written about challenge trials in May 2020, and was so compelled by the idea that I put my name on a list of volunteers that scientists could call on if they organized such a trial. I thought I was a good candidate because I had no conditions that would make me unusually vulnerable to Covid-19. Because of the nature of my work, I could call on the world's top experts to advise me about safety and scientific value of any trial I might enter.

At the time, nobody knew how long it would take to get vaccines tested and approved. Challenge trials have been used to study malaria and influenza and looked like a possible shortcut to speed up arrival of a Covid-19 vaccine. For me, the experience would have led to a series of great stories. Journalists do far more dangerous things for work.

But events took a surprising turn. Standard vaccine trials progressed with record speed and the first vaccine candidates looked impressively effective. By the end of 2020, vaccines were already being offered to health-care workers in some places. I'd assumed any challenge trials would have been called off.

But the challenge trial Hopkins took part in did go forward. "We started with the lowest dose we can reliably produce," said Christopher Chiu, a researcher at Imperial College London, who headed the experiment. If nobody got infected they'd step up the dose, slightly, he said, but on the first try, they got slightly past 50% — infecting 18 of 34 volunteers.

Chiu said they are only beginning to learn from the data they've accumulated. Two of the 18 infected had no symptoms at all, and the rest had mild or moderate symptoms — mostly sore throats and runny noses.

One of the first big surprises was how short the incubation period was, Chiu told me. It was only two days before the volunteers who got infected tested positive on PCR tests and not much longer to register a positive on rapid tests. Those who got symptoms noticed them between two and four days after exposure.

Another surprise was that the amount of virus people produced didn't reflect the severity of their symptoms — those who produced a lot of virus sometimes had very mild or no symptoms and those who felt sicker sometimes produced less.

Since the date of exposure was known, the data were also useful for examining testing efficacy. While rapid tests didn't always pick up the infection as early as the more sensitive PCR test, Chiu said it appeared to pick up most infections around the time that would likely coincide with peak transmissibility.

Chiu said everyone recovered quickly from all the symptoms except for changes in taste and smell. Those lasted for around six months in five of the volunteers, and one was still reporting a diminished sense of smell nine months after exposure.

Since this experiment took place, there's been big increase in the awareness of the risk of lingering or even permanent symptoms, and several studies have hinted at the possibility of long-term changes in the heart and brain, though scientists are still trying to figure out if the subtle changes have real health significance.

Hopkins, who works for the charity group Citizens' Advice, said he was well aware of the risk of long Covid, but thinks it was outweighed by the benefit of being part of the fight against the pandemic. He feels that the researchers fully informed him of the risks of infection and what would be involved in the experiment. He told me he is a risk-taker by nature, and recently went skydiving in Dubai. "I love adrenaline," he said. And he's deeply interested in medical research and has donated stem cells to people with blood cancers.

The course of his illness was brief. He was infected on a Monday, tested positive on Wednesday and started feeling chills on Thursday. He said he had flulike symptoms that were "pretty rough" but lasted only two days. Then, a few days after feeling better, while still in isolation and undergoing tests, he failed a smell test. Odors on the test that had been strong before his infection smelled like absolutely nothing. Then a few days later, his sense of smell returned.

Challenge trials give scientists a uniquely controlled data set, helping them gauge things like incubation time, accuracy of tests and long-term consequences of infection. They may reveal something about why some people get sick and others don't. It's the kind of controlled, experimental data that's been so badly lacking in a pandemic that's been ruled by educated guesses announced with inappropriate certainty.

The situation has changed a lot since this experiment was done. We're contending with descendants of Omicron — BA.2, BA.2.121, BA.4 and BA.5, and almost everyone in the U.K. and the U.S. has some degree of immunity to some version of the virus. But the challenge trial data could nevertheless be extremely useful right now. Those data suggest that people who test positive may remain infectious far longer than the five days they're supposed to quarantine. And for those potentially exposed, the data could be turned into better information on when to use home or PCR tests, and how much people can rely on the results. The challenge trial results also open up new scientific questions, including why some people resist getting infected at all — even when the virus is sprayed directly up their noses.


Faye Flam is a Bloomberg Opinion columnist and host of the podcast "Follow the Science."
 

Disclaimer: This article first appeared on Bloomberg, and is published by special syndication arrangement.
 

Coronavirus chronicle / Features / Top News

Covid -19 / Coronavirus

Comments

While most comments will be posted if they are on-topic and not abusive, moderation decisions are subjective. Published comments are readers’ own views and The Business Standard does not endorse any of the readers’ comments.

Top Stories

  • Wreckage of a Boeing 787 Dreamliner showing part of its registration "VT-ANB" in Ahmedabad, India, June 12, 2025. REUTERS/Amit Dave
    All 242 people on board Air India plane have died
  • CA Yunus meets King Charles
    CA Yunus meets King Charles
  • News of The Day, 12 JUNE 2025
    News of The Day, 12 JUNE 2025

MOST VIEWED

  • File photo of ex-prime minister Sheikh Hasina and her son Sajeeb Wazed Joy. Photo: Collected
    Joy spends Eid with Hasina in India: Indian media
  • Infofgraphics: TBS
    DGHS issues 11-point directive to prevent spread of Covid-19 in Bangladesh
  • Saifuzzaman Chowdhury. Photo: Collected
    UK crime agency now freezes assets of ex-land minister Saifuzzaman: AJ
  • File photo of BNP Standing Committee Member Amir Khasru Mahmud Chowdhury. Photo: Collected
    Khasru flies to London ahead of Yunus-Tarique meeting
  • Chief Adviser Muhammad Yunus speaks at the Chatham House in London on 11 June 2025. Photo: CA Press Wing
    No desire to be part of next elected govt: CA Yunus
  • Illustration: Khandaker Abidur Rahman/TBS
    Three hospitals ‘held hostage’ as discharged July uprising injured keep occupying beds

Related News

  • Covid hospitals in Chattogram face ICU, testing kit crisis amid rising infections
  • 10 more Covid-19 cases reported in country
  • DGHS issues 11-point directive to prevent spread of Covid-19 in Bangladesh
  • Tourist surge raises fresh Covid-19 concerns in Rangamati
  • Aid funding disrupts child vaccinations almost as much as pandemic: UN

Features

Among pet birds in the country, lovebirds are the most common, and they are also the most numerous in the haat. Photo: Junayet Rashel

Where feathers meet fortune: How a small pigeon stall became Dhaka’s premiere bird market

1d | Panorama
Illustration: Duniya Jahan/ TBS

Forget Katy Perry, here’s Bangladesh’s Ruthba Yasmin shooting for the moon

1d | Features
File photo of Eid holidaymakers returning to the capital from their country homes/Rajib Dhar

Dhaka: The city we never want to return to, but always do

3d | Features
Photo collage shows political posters in Bagerhat. Photos: Jannatul Naym Pieal

From Sheikh Dynasty to sibling rivalry: Bagerhat signals a turning tide in local politics

5d | Bangladesh

More Videos from TBS

What exactly happened to the ill-fated Boeing aircraft?

What exactly happened to the ill-fated Boeing aircraft?

1h | TBS World
Govt to set up Debt Office as loan burden to hit Tk29 lakh cr by FY28

Govt to set up Debt Office as loan burden to hit Tk29 lakh cr by FY28

1h | TBS Insight
Curfew imposed for second night in Los Angeles

Curfew imposed for second night in Los Angeles

2h | TBS World
When will coronavirus testing start in hospitals?

When will coronavirus testing start in hospitals?

2h | TBS Today
EMAIL US
contact@tbsnews.net
FOLLOW US
WHATSAPP
+880 1847416158
The Business Standard
  • About Us
  • Contact us
  • Sitemap
  • Advertisement
  • Privacy Policy
  • Comment Policy
Copyright © 2025
The Business Standard All rights reserved
Technical Partner: RSI Lab

Contact Us

The Business Standard

Main Office -4/A, Eskaton Garden, Dhaka- 1000

Phone: +8801847 416158 - 59

Send Opinion articles to - oped.tbs@gmail.com

For advertisement- sales@tbsnews.net